Animal reproduction experiments have not been executed Using the drug blend–promethazine and phenylephrine. It isn't regarded regardless of whether this drug mix could cause fetal damage when administered to the pregnant lady or can have an affect on reproduction capability. Promethazine and phenylephrine really should be offered into a Expecting girl provided that Evidently required.
Promethazine is nicely absorbed from the gastrointestinal tract. Scientific effects are evident within twenty minutes soon after oral administration and customarily very last 4 to six hrs, Even though they may persist given that twelve several hours.
Antihistamines are contraindicated for use during the treatment method of reduced respiratory tract symptoms, together with asthma.
Promethazine is contraindicated in comatose states, and in folks regarded to be hypersensitive or to possess had an idiosyncratic reaction to promethazine or to other phenothiazines.
In pediatric people who will be acutely sick linked to dehydration, There exists a heightened susceptibility to dystonias with the use of promethazine HCl.
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It really is soluble in h2o and freely soluble in alcohol. It's got a molecular fat of 320.88, a molecular components of C17H20N2S • HCl, and the following structural formulation:
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Promethazine: Lengthy-expression animal studies haven't been carried out to assess the carcinogenic prospective of promethazine, nor are there other animal or human info regarding carcinogenicity, mutagenicity, or get more info impairment of fertility with this drug. Promethazine was nonmutagenic while in the Salmonella examination method of Ames.
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